Active ingredient: 1 g TRETIN contains 500 mcg Retinoic Acid (Tretinoin).

Excipients: Isopropyl myristate, Carbopol 1342, Polysorbate 80, Migliol 812, Glycerol, Liquid paraffin, Butyl hydroxytoluene (E321), Butyl hydroxyanisole (E320), Methyl parahydroxybenzoate (E218), Propyl parahydroxybenzoate (E216), Sodium hydroxide, Purified water.

Before you start using this medicine, read this INSTRUCTIONS FOR USE carefully, because it contains important information for you.

TRETIN contains retinoic acid (tretinoin) as the active ingredient.

Retinoic acid (tretinoin), the active ingredient of TRETIN, stimulates the renewal of cells of the epidermis, the top layer of the skin, when applied to the skin, suppresses excessive keratin formation and stimulates the skin’s self-repair mechanisms.

Formulated in a special cream base that is easily accepted by the skin, TRETIN regulates blood circulation in the skin and strengthens the skin texture by tightening the pores. It also stimulates collagen production in the skin and tightens and thins the top layer of the skin.

Instructions for proper use and dosage/frequency of administration

TRETIN is applied to the skin once a day at night.

There may be a temporary feeling of warmth and stinging on the skin upon application. If necessary, the dose that the patient can tolerate can be adjusted by interrupting the treatment or reducing the frequency of application.

There may be an increase in inflammatory lesions (inflammatory disorder/damage to the skin) during the first weeks of treatment. This is due to the effect of the drug on the lesions and does not require discontinuation of the drug.

Treatment results appear after 2-3 weeks, but more than 6 weeks may be required to achieve full benefit.

Like all medicines, TRETIN may have side effects in people who are sensitive to its ingredients.

If any of the following occur, stop using TRETIN and IMMEDIATELY inform your doctor or go to the emergency department of your nearest hospital:

If you have one of these, it means you are seriously allergic to TRETIN. You may need emergency medical attention or hospitalization.

If you notice any of the following, tell your doctor:

If you experience any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.